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Biology 351 -Developmental Biology

Note tostudents: all material for this course is available on Angel

Overview:

Developmental Biology is the study ofthe molecular and cellular events that lead to the generation of amulticellular organism from a fertilized egg.  Although much isknown about the morphological changes that take place duringdevelopment, there is a lesser understanding of the mechanisms by whichthese changes occur.  Because of this lack of knowledge, andbecause of the interest in understanding how something as complex as ahuman being can develop from a single cell, Developmental Biology isone of the most active areas of biological research today.

In essence, Developmental Biology is a study of cell differentiation; to its extreme extent, development of an entire organism from a single cell involves severalstages of differentiation and cell interaction.  The course willinvestigate the cellular and molecular processes involved in generatingan embryo, in creating various tissues and organs, and the effect ofexternal stimuli on development.

photo:chick embryo, Biology 351L, Spring 2003


Course::

Upon completion of this course,students will be expected to:

    * Be familiar with the genes and cellular mechanismsresponsible for development.
    * Understand the cellular and molecular eventsinvolved in the generation and fusion of gametes prior to and during fertilization.
    * Describe the morphological changes that occurduring early embryogenesis, including the events of cleavage, axis formation, gastrulation, and neurulation.
    * Understand how tissue layers form and howdifferent organs are derived from each embryonic layer.
    * Understand how gene expression and cell signaling regulate developmental processes, and how cells with identical DNAcontent can have different developmental fates.
    * Be able to identify several organisms used forstudying developmental processes, and describe the similarities foundin the development of these very dissimilar organisms.
    * Establish the relationship between developmental biology and other branches of biology such as anatomy, ecology, andevolution.

Prerequisites::
Students who take this courseshould have successfully completed Biology 142 and 142 (lecture andlab).  It is recommended (but not required) that students take a 200- level laboratory course prior to taking Biology 351. Students must concurrelty enroll in the lecture and laboratory portionsof the course.

Sample Syllabus::
1 Welcome and Introduction (lecture and lab)
2 Introduction to developmental biology
3 Basic developmental patterns and life cycles
4 Cell specification and morphogenesis
5 Genes and development
6 Differential gene expression
7 Cell communication
 ***** EXAM I *****
8 Fertilization
9 Cleavage and gastrulation
10 Drosophila development
11 Amphibian development
12 Early development in higher vertebrates
 ***** EXAM II *****
13 Neurulation and epidermis generation
14 Neural crest and the peripheral nerves
15 Myogenesis, osteogenesis, and urogenesis
16 Cardiac and visceral development
17 Limb development
18 Sex determination
 ***** EXAM III *****
19 Metamorphosis, regeneration,and aging
20 Germ cells, spermatogenesis,and oogenesis
21 Medical embryology
22 Environmental Influence ondevelopment
23 Implications for evolution
 ***** EXAM IV *****

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