Purpose: The purpose of this study was to determine the difference in strength of the dominant quadriceps femoris muscle group among subjects utilizing an Nautilus training system, and a traditional weight system. Method: Eighteen college students, 18-23 years of age, volunteered for this study. Subjects were randomly assigned to one of three groups: Group N, Nautilus training system, consisted of six subjects utilizing the Nautilus knee extension machine, performing one set of 15 repetitions to failure, using a 15 repetition maximum (RM) at a count of 5 contract - 1 hold - 5 release. Group T, traditional, consisted of five subjects utilizing an NK table, performing three sets of 10 repetitions at 10 RM following a count of 1 contract - 1 release. Group C, control, consisted of seven subjects who did not undergo any training. The three groups were pre-tested for bilateral quadriceps femoris strength 1 week prior to training, and retested 7 weeks later on the Cybex II Dynamometer. Results: Results of this study, using an ANOVA with F-ratio, demonstrated that the strength gain of the dominant quadriceps femoris muscle was not significantly different between the three groups (p>0.05). However, group T was significantly stronger that group N and Group C in average quadriceps strength (p<0.05). In addition, there was a tendency for group T to demonstrate increased strength gains for all analyses. Conclusion: The authors contend that further investigation must be made to determine whether either method of exercise is superior at increasing quadriceps femoris strength.